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Furthermore, D. As such, D. Using the many behavioral assays and genetic tools available in D. Of particular importance is D. Here, we discuss in detail the social behaviors: social spacing, response to stressed flies, sociability, courtship, courtship conditioning, aggression, social learning of egg laying, structure of social interaction networks, social entrainment of circadian rhythm, and length of mating in presence of competitors. All motile organisms, from bacteria to humans, including D. Social spacing is similar to aggregation, except social spacing can take place in the absence of food and is dependent upon interactions among flies already in groups.

Thus, social aggregation studies have set the stage for studies on social spacing. Social spacing often takes place prior to other social behaviors, as individuals must be oriented properly and in close proximity in order to interact and transfer cues to one another. Hence, social spacing is more complex than aggregation.

Factors that contribute to social spacing will depend on the nature of the interaction between individuals and the group. Whereas courtship would promote more proximal interactions, mate competition or male aggression may promote more distal interactions. Social spacing and social avoidance may be emergent behaviors that arise in groups when individuals try to avoid others in the same group.

Human aging

This may be achieved through stigmergy, where individuals leave a mark on the environment that is interpreted by another individual in the group, which then influences spatial orientation and distance to their nearest neighbor, a process that can feed back onto the whole population. For example, in herd immunity, individuals who are not infected would be closer to the group while others may be isolated or even quarantined when infected.

This effect was more pronounced in females than in males. How do the flies perceive the presence and distance of other flies, so that they establish their preferred social space? Group formation is influenced by cVA, which has been shown to be an aggregation pheromone. Similarly, vision, which might be more discerning than previously thought, is playing a role in social interaction networks, despite having only a limited effect on social spacing.

Social spacing in D.

Phase I: “Late-Life Depression”

The condition and previous experiences of the fly can affect social spacing. Socially isolated flies are more distal, and therefore less social, an effect that is more pronounced in females than in males. This behavioral pattern was transgenerational, inherited to the next generation in both sexes. Social spacing can also be affected by exposure to environmental toxins. For example, increasing concentrations of the chemical Bisphenol A linked to neurodevelopmental disorders and other health effects , in D.


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The neural bases of social spacing are starting to be elucidated. The neurotransmitter acetylcholine, in the mushroom bodies, as well as DA signaling, studied through mutations in tyrosine hydroxylase, Catsup a negative regulator of tyrosine hydroxylase , and vesicular monoamine transporter have all been implicated. Specifically, tyrosine hydroxylase is important for the response to social isolation in dopaminergic neurons in the PPM2 cluster, in males. For example, the human gene neurobeachin , which encodes a large scaffolding protein, has been identified as a candidate gene for ASD.

We propose a model to describe and integrate the mechanisms currently known to affect social spacing through age in Figure 2. The precise components of courtship behavior and their sequence in D. Courtship is an elaborate social behavior involving various sensory cues eg, visual, auditory, olfactory, tactile that can influence both the female's and male's behaviour. Many internal eg, female sexual maturity and external eg, environmental conditions factors can influence courtship and receptivity, and studies on courtship activity need be mindful of these influences on behavior.

Even magnetic fields have recently been shown to increase male courtship activity, highlighting the breadth of sensitivity this behavior has to variation in conditions. Courtship is affected by aging. Younger males are more selective when choosing a mate than older males, preferring to mate with larger, younger, unmated females. Virgin females are also able to distinguish between the sons of fathers of different ages. Since both latency to courtship and copulation duration are heritable measures, it is possible that there is a genetic basis to the differential success of sons from young vs old fathers, although more studies are needed to confirm this effect of behavioral inheritance with aging.

Female behavior during courtship also varies with aging. Males initiate courtship faster reduced courtship latency if the female being courted has had more previous matings, but this effect is decreased as females age. This shows that males are less eager to court older females that have a longer mating history. The expression of some genes involved in courtship also change with aging. Three genes known to affect male courtship eagle, pale, yellow have reduced expression as males age.

They are thought to be important in early adult development, such as for proper pigment allocation, and thus may have reduced importance later in life. These genes may be upregulated with aging if they are necessary later in life for adult behavior, including courtship. Evidence suggests that fruitless expression with aging can sensitize Or47b expressing neurons and give older males an advantage over younger males in mate competition by filtering sensory stimuli and aiding discrimination between younger and older females see Reference for a review.

Increases in fruitless expression could be controlled in part by hormonal regulation eg, juvenile hormone as flies age. Natural decreases in DA levels or deterioration of dopaminergic cells with aging are associated with decreases in male courtship and female receptivity.

Genetics Of Aging - iBiology & Youreka Science

In flies, courtship behavior is vigorously performed by males, at least as observed in laboratories. However, upon exposure to unreceptive mated females, males will learn to reduce courtship. When flies are stressed or mechanically agitated in the lab, they will emit a volatile chemical substance called the D.

However, these are not the same brain structures that are involved in olfactory learning. Therefore, dSO avoidance is an innate behavior and not a learned response. Emission of dSO does not change with age of the emitters. Individuals are less able to avoid the odorants produced by stress when they are older or when they are still young but their parents have been aged. To determine how this response to stress occurs in flies of all ages and how it is altered in flies with aging requires further investigation. In order to elucidate the underlying molecular mechanisms or neural circuitry required for this response, the components of dSO, besides CO 2 , need to be determined.

Only then can the sensory modalities responsible for dSO processing be investigated. This behavior is required for survival as individuals often compete over food, mates, and territory. Signals including pheromone sensing, food presence, and visual cues, each operating through different pathways to elicit a behavioral response. Therefore, individuals must identify potential competitors based on behavioral cues and chemical cues, such as cuticular hydrocarbons.

Aggression varies with aging, while dominance, the hierarchy established based on the outcomes of aggressive encounters, is stable over time.

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We propose that based on what is known about the aging process in the structural and molecular substrates for social behavior, a series of additional social behaviors are also likely to change with aging. Social aggregation, which is similar to social spacing discussed above , is social clustering in the presence of a resource such as food.

Social spacing has recently been shown to change with aging, and thus social aggregation may also change with aging. Social isolation has the same effect on sociability as on social space: the flies are less close, and less social lower sociability score. Social learning was first described in as a behavior in which individuals will learn and make choices based on the cues of another individual.

Therefore, these flies must be able to either filter information, selectively choose to follow some cues over others, or integrate the information together before making a decision about egg laying. It is still unknown how aging affects social learning. Since the cuticular hydrocarbon profile changes with aging, it is possible that the profile of the pheromones deposited on the egg also change with aging.

If so, then social learning, which depends on these cues, would also be affected. Furthermore, if the capacity to sense and interpret these cues is diminished with age, this would also impact social learning. Finally, both serotonin and DA are required for social learning. Social learning, social space or distance , and probably sociability too, are the outcome of a complex exchange of information, taking place within social interaction networks. The receipt and processing of these cues subsequently can impact where a fly settles in a group, where they lay their eggs, and whether they avoid particular odors.

Vladimir Dilman elaborates on the wear and tear theory by focusing on the neuroendocrine system. When young, the hormones work together to regulate many bodily functions, including the responses to heat and cold, life experiences and sexual activity. Different organs release various hormones all under the governance of the hypothalamus. The hypothalamus responds to the body's hormone levels as its guide to regulating hormonal activity. When young, hormone levels tend to be high. With the increase in the age, the body produces lower levels of hormones which can have disastrous effects on the functioning.

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IBPS | Biological adaptation and ageing

The growth hormones, for example, drop dramatically as the age increases so that even if an elderly person has not gained weight, he or she has undoubtedly increased the ratio of fat-to-muscle. Hormones are vital for repairing and regulating the bodily functions, and when aging causes a drop in the hormone production, it causes a decline in body's ability to repair and regulate itself as well.

Thus, hormone replacement therapy, a frequent component of any anti-aging treatment, helps to reset the body's hormonal clock and so can reverse or delay the effects of aging and thus keeping young Gavrilov and Gavrilova, This theory states that humans are born with a unique genetic code, a predetermined tendency to certain types of physical and mental functioning, and that the genetic inheritance has a great deal to say about how quickly one becomes aged and how long lives.

Each person has a biological clock. When that clock goes off, it signals the bodies first to age and then to die. However, the timing on this genetic clock is subject to enormous variation, depending on what happens with the growth and on how one actually lives quality of life, feeding, sanitation, health care practices, etc Bengtson and Schaie, In the course of life span the cells produce more waste than they can properly eliminate.

This waste can include various toxins which when accumulated to a certain level, can interfere with normal cell function, ultimately killing the cell.


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Evidence supporting this theory is the presence of a waste product called lipofuscin leading to age pigment. Lipofuscin is formed by a complex reaction that binds fat in the cells to proteins.


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This waste accumulates in the cells as small granules and increases in size as a person ages Gavrilov and Gavrilova, The number of cell divisions is directly affected by the accumulations of the cell's waste products. The more wastes accumulates over the time, the faster cells degenerate Bengtson and Schaie, In , two cell biologists, Dr. Hayflick and Dr. Moorehead, made one of the greatest contributions to the history of cellular biology by demonstrating the senescence of cultured human cells. Hayflick theorized that the aging process was controlled by a biological clock contained within each living cell.

The studies concluded that human cells have a limited life span. The most evident changes took place in the cell organelles, membranes and genetic material. This improper functioning of cells and loss of cells in organs and tissues may be responsible for the effects of aging Hayflick and Moorehead, Unlike other cells, brain cells or neurons do not replicate.